Benzenesulfonic acids and derivatives
Medchemexpress LLC QL-X-138 | 1469988-63-3 | 99.8% | 421.45 | C25H19N5O2 | 1MG
QL-X-138 is a small-molecule BTK/MNK dual kinase inhibitor that covalently binds to BTK and non-covalently to MNK. It is provided as a high-purity solid for laboratory research and has been characterized in preclinical studies for activity against hematologic malignancies and dengue virus.
- Dual inhibition of Bruton tyrosine kinase (BTK) and MAPK-interacting kinase (MNK).
- Covalent binding to BTK and non-covalent binding to MNK.
- High-purity solid form suitable for laboratory research.
- Molecular formula C25H19N5O2 and molecular weight 421.45.
- Demonstrated preclinical activity in models of lymphoma, leukemia, and dengue virus.
- For research use only; not for human or clinical use.
eMolecules 80-48-8 | Methyl p-toluenesulfonate | Combi-Blocks | MFCD00008417 | 186.230 | C8H10O3S | 95.000 | COS(=O)(=O)c1ccc(C)cc1 | 25g | 415498342
Methyl p-toluenesulfonate | Combi-Blocks | 80-48-8 | MFCD00008417 | 186.230 | C8H10O3S | 95.000 | COS(=O)(=O)c1ccc(C)cc1 | 25g | 415498342
Cayman Chemical a-KetoglutarIc AcId 500g
An intermediate in the citric acid cycle; precursor of glutamine and glutamate and an antioxidant with roles in immune homeostasis, aging, protein synthesis, and bone development
Cayman Chemical 2 4-Dinitrobenzenesulfonic Ac
A hapten; induces the proliferation of primary lymphocytes and epithelial cells isolated from 2,4-DNCB-sensitized guinea pigs at 25, 50, or 100 ppm; inhibits 2,4-DNCB-induced contact sensitivity in 2,4-DNCB-sensitized guinea pigs at 600 mg/kg; has been used to induce ulcerative colitis in rats
Apexbio Technology LLC L-732,138 148451-96-1 50mg
L-732 138 (CAS 148451-96-1) is a potent and selective antagonist of the neurokinin-1 (NK-1) receptor exhibiting an IC50 of 2 3 nM Comparative studies demonstrate its affinity for the human NK-1 receptor is approximately 200-fold higher than for the rodent NK-1 receptor and markedly greater than for human NK-2 and NK-3 receptors By inhibiting NK-1 receptor-mediated signaling L-732 138 has been shown to attenuate hyperalgesia and display anti-tumor properties in preclinical models Its receptor selectivity and biological activity make it a valuable tool for investigating NK-1 receptor function and associated pathophysiological processes
Medchemexpress LLC I-138 | 2098211-50-6 | C26H23F3N6O | 1 ML
I-138 is an orally active, reversible inhibitor of USP1-UAF1, with an IC50 of 4.1 nM and Ki of 5.4 nM. It induces monoubiquitination of FANCD2 and PCNA in cells and eliminates USP1 autocleavage in cells. It is intended for research use only.
- Eliminates USP1 self-lysis in HAP-1 USP1 WT and knockout cells
- Induces monoubiquitination of FANCD2 and PCNA in MDA-MB-436 cells
- Dose-dependently inhibits MDA-MB-436 cell viability
- Results in USP1 inhibition and modest antitumor activity in mice bearing MDA-MB-436 tumors
- Benefits BRCA1/2 mutant tumor inhibition in vivo when combined with Niraparib
Organix Inc HEPTADECAN-9-YL 8-//2-HY 100MG
Heptadecan-9-yl 8-((2-hydroxyethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate (Sm102, Lipid 8) 100mg
Sigma Aldrich Fine Chemicals Biosciences alpha Ketoglutaric acid so1KG
alpha Ketoglutaric acid so1KG
Medchemexpress LLC 5-Sulfosalicylic acid | 97-05-2 | 98.7% | 100 MG
5-Sulfosalicylic acid is a sulfonated salicylic acid derivative that demonstrates effectiveness against breast cancer cell lines with reduced toxicity. Additionally, it exhibits antioxidant activities.
- Effective against breast cancer cell lines with less toxicity.
- Possesses antioxidant activities.
Medchemexpress LLC Acid Yellow 9 monosodium salt | 74543-21-8 | 98.0% | 1 G
Acid Yellow 9 monosodium salt is an azo dye, degraded by Pseudomonas fluorescens as the sole source of carbon, nitrogen, and energy for the bacterium. It is an orange to red solid that is stable under recommended storage conditions.
- Azo dye
- Degraded by Pseudomonas fluorescens
- Molecular Weight: 379.34
- Formula: C12H10N3NaO6S2
- Appearance: Solid
- Color: Orange to red
- Stable under recommended storage conditions
- Incompatible with strong acids/alkalis, strong oxidising/reducing agents
- Storage: 4°C, sealed, away from moisture and light; in solvent: -80°C, 6 months; -20°C, 1 month
- Solubility (In Vitro): DMSO : 20 mg/mL (52.72 mM; ultrasonic and warming and heat to 60°C)
Sigma Aldrich Fine Chemicals Biosciences alpha Ketoglutaric acid 981KG
alpha Ketoglutaric acid 981KG
Medchemexpress LLC Cromolyn disodium | 15826-37-6 | 99.98% | 5 G
Cromolyn disodium is an orally active GSK-3β inhibitor and a mast cell stabilizer. It inhibits the release of mediators from mast cells, regulates reflex bronchoconstriction, and reduces non-specific bronchial hyperreactivity. It is used in the research of bronchial asthma and exhibits anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects.
- Orally active GSK-3β inhibitor
- Mast cell stabilizer
- Inhibits mediator release from mast cells
- Regulates reflex bronchoconstriction
- Reduces non-specific bronchial hyperreactivity
- Anti-inflammatory properties
- Anti-allergic effects
- Anti-histamine activity
- Anti-cancer properties
- Neuroprotective effects